The plot is focused primarily on the dilemmas the group faces as they struggle to balance their humanity with their survival against the zombie horde, and later, how they cope with members being killed and deal with other human survivors they encounter, many of whom are dangerous and predatory themselves.
The group is led by Rick Grimes, who was a sheriff's deputy before the zombie outbreak. At every turn they are faced with the horror of the dead walking again, the changing dynamic of their group, and hostility from the scattered remains of a struggling human populace who are focused on their own survival now that the structures of society have collapsed.